Apolipoprotein E Genotype, Plasma Cholesterol, and Cancer: A Mendelian Randomization Study
نویسندگان
چکیده
منابع مشابه
Apolipoprotein e genotype, plasma cholesterol, and cancer: a Mendelian randomization study.
Observational studies have shown an association between low plasma cholesterol levels and increased risk of cancer, whereas most randomized clinical trials involving cholesterol-lowering medications have not shown this association. Between 1997 and 2002, the authors assessed the association between plasma cholesterol levels and cancer risk, free from confounding and reverse causality, in a Mend...
متن کاملLow-density lipoprotein cholesterol and the risk of cancer: a mendelian randomization study.
BACKGROUND Low plasma levels of low-density lipoprotein (LDL) cholesterol are associated with an increased risk of cancer, but whether this association is causal is unclear. METHODS We studied 10 613 participants in the Copenhagen City Heart Study (CCHS) and 59 566 participants in the Copenhagen General Population Study, 6816 of whom had developed cancer by May 2009. Individuals were genotype...
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Background: Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods. Methods: The associations of BMI with cardiovascular outcomes [coronary heart disease (CHD), heart failure and ischaemic stroke], and associations o...
متن کاملApolipoprotein E polymorphism and plasma cholesterol response to probucol.
Probucol has been shown to be an effective and well-tolerated cholesterol-lowering drug. However, response in terms of cholesterol reduction has been shown to vary significantly among individuals. The purpose of this study was to assess the role of apolipoprotein E polymorphism in determining this variation. A retrospective study of 89 hypercholesterolemic type II patients who had been treated ...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2009
ISSN: 0002-9262,1476-6256
DOI: 10.1093/aje/kwp294